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KMID : 0370920130300010017
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Yeungnam Univercity Journal of Medicine
2013 Volume.30 No. 1 p.17 ~ p.20
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A Case of ANCA-Negative Generalized Wegener’s Granulomatosis
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Kim Seung-Kyu
Kwon Yong-Jin
Park Heae-Surng
Lee Kwang-Won
Ha Ji-Yoon
Ko Hee-Sung
Kim Ki-Hyun
Byun Min-Kwang
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Abstract
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Wegener’s granulomatosis is a very rare systemic vasculitis characterized by necrotizing granulomatosis. The detection of antineutrophil cytoplasm antibody (ANCA) is a valuable finding in diagnosing Wegener’s granulomatosis because ANCA is positive in approximately 90 percent of patients with active, generalized Wegener’s granulomatosis. But ANCA is not necessarily positive to make a diagnosis. A 59-year-old man was transferred to our hospital. He was diagnosed with lung abscess and treated with antibiotics at previous hospital. Initially, the ANCA was negative in immunofluorescence assay but we suspected Wegener’s granulomatosis because of systemic inflammatory symptoms. Clinical symptoms deteriorated rapidly so we did bronchoscopic biopsy early. Wegener’s granulomatosis was diagnosed according to pathologic finding that reported necrotizing granulomatous inflammation associated with vasculitis. Thus we treated with steroid then clinical symptoms and laboratory findings were improved.
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KEYWORD
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Wegener’s granulomatosis, ANCA
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